New vaccine lowers blood pressure without harming kidneys
Vaccination against a pressure-raising hormone safely lowered blood pressure in rats for up to six months, in early tests presented at the American Heart Association’s Scientific Sessions 2013.
The new DNA vaccine targets angiotensin II, a hormone that increases blood pressure by causing blood vessels to constrict. Medications that block the action of angiotensin II are widely used to control blood pressure, but must be taken daily to be effective.
In the study, blood pressure was reduced for up to six months in animals receiving the vaccine, and tissue damage associated with high blood pressure to the heart and blood vessels was reduced.
The vaccine didn’t cause any dangerous autoimmune reactions and there were no signs of damage to the kidney, heart or liver in the treated animals.
Researchers said they hope their Ang II DNA vaccine may one day offer a new treatment option for patients with high blood pressure.
Stories available for linking, quoting, excerpting, reprinting
Stories appearing on blog.heart.org under the "By American Heart Association News" byline are available for linking, quoting, excerpting and reprinting. Copyright is owned or held by the American Heart Association, Inc., and all rights are reserved. Permission is granted, at no cost and without need for further request, to link to, quote, excerpt or reprint from these stories in any medium as long as no text is altered and proper attribution is made to the American Heart Association. Additional conditions may apply to the use of these stories in printed materials.
American Heart Association additional conditions for linking, quoting, excerpting, reprinting stories in print media
- A credit line of American Heart Association News must be prominently placed on the page in which the American Heart Association materials appear.
- The American Heart Association logo and service marks may only be used if they appear on the materials requested.
- Stories reprinted may be edited for length, but no other deletions, alterations or other changes may be made without the prior written consent of the American Heart Association.
- Artwork labeled "American Heart Association" may be reprinted, but other artwork may not. For artwork permission questions, contact email@example.com
- Stories reprinted may not be placed adjacent to any advertisement, photo, graphic or other content that could be considered inappropriate by the American Heart Association. For questions about whether content is inappropriate, contact firstname.lastname@example.org.
- Stories may not be displayed in any way that gives the appearance that the American Heart Association endorses (implied or otherwise) or is affiliated with any product, service or company.